USP5 MOTIVATES IMMUNOSUPPRESSIVE MICROENVIRONMENT IN MULTIPLE MYELOMA BY ACTIVATING STAT2-PFKFB4-MEDIATED GLYCOLYSIS

USP5 motivates immunosuppressive microenvironment in multiple myeloma by activating STAT2-PFKFB4-mediated glycolysis

Abstract Background Glycolysis, a classic characteristic of cancer cells, can drive cancer progression by generating lactate, which play as a key immunosuppressive mediator.Currently, ubiquitin-specific proteases 5 (USP5) has been demonstrated to facilitate tumor cell survival in multiple myeloma (MM), whereas whether USP5 was involved in glycolysi

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HOW TO GET GOOD PRODUCTION PROCESS?

In every realization of the production process certain input materials (raw materials, energy, information), management (adjustment, checking, inspection) and necessary resources (equipment, machines, computers) are included in order to obtain production results.Process results can be necessary for processed materials, finished products, management

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Distinct roles for the domains of the mitochondrial aspartate/glutamate copyright citrin in organellar localization and substrate transport

Objective: Citrin, the mitochondrial aspartate/glutamate copyright isoform 2 (AGC2), is structurally and mechanistically the most complex SLC25 family member, because it consists of three domains and forms a homo-dimer.Each protomer has an N-terminal calcium-binding domain with EF-hands, followed by a substrate-transporting copyright domain SINGLE-

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Mentoring and gender: a systematic review

The incorporation of a gender perspective in scientific research and social intervention practices is essential, including in mentoring.While there are publications that address this issue, existing systematic reviews tend to focus on specific contexts and groups, rather than taking a general approach to introducing a gender perspective.This study

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